Kleber G Franchini Selected Research

4- ((3- bromophenyl)amino)- 6,7- dimethoxyquinazoline

5/2010	Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.
12/2009	EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.

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Kleber G Franchini Research Topics

Disease

10	Hypertrophy 01/2012 - 04/2003
4	COVID-19 10/2022 - 01/2021
3	Weight Loss (Weight Reduction) 01/2017 - 01/2008
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 03/2011 - 04/2003
3	Fibrosis (Cirrhosis) 12/2009 - 10/2002
2	Inflammation (Inflammations) 01/2021 - 12/2009
2	Premature Birth (Birth, Premature) 01/2019 - 01/2016
2	Neoplasms (Cancer) 10/2018 - 07/2006
2	Hypertension (High Blood Pressure) 08/2011 - 10/2002
2	Cardiomegaly (Heart Hypertrophy) 12/2009 - 12/2007
2	Insulin Resistance 12/2009 - 12/2003
2	Obesity 01/2008 - 07/2006
2	Diabetes Mellitus 04/2007 - 10/2002
2	Type 2 Diabetes Mellitus (MODY) 04/2007 - 07/2006
1	Ageusia (Hypogeusia) 10/2022
1	Erythema 10/2022
1	Virus Diseases (Viral Diseases) 10/2022
1	Viral Pneumonia 01/2022
1	Pneumonia (Pneumonitis) 01/2022
1	Heart Failure 01/2020
1	Endotoxemia 01/2012
1	Hypotension (Low Blood Pressure) 01/2012
1	Sepsis (Septicemia) 01/2012
1	Ventricular Remodeling 08/2011
1	Vascular Remodeling 05/2011
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 03/2011
1	LEOPARD Syndrome (Syndrome, LEOPARD) 03/2011
1	Ischemia 05/2010
1	Aortic Valve Insufficiency (Aortic Regurgitation) 11/2009
1	Myocardial Infarction 10/2008
1	Sickle Cell Anemia (Hemoglobin S Disease) 10/2008
1	Anorexia 01/2008
1	Communicable Diseases (Infectious Diseases) 07/2006
1	Bradycardia 07/2005
1	Hypoxia (Hypoxemia) 07/2005
1	Cardiovascular Abnormalities 12/2003

Drug/Important Bio-Agent (IBA)

5	TOR Serine-Threonine KinasesIBA 01/2017 - 01/2008
4	Small Interfering RNA (siRNA)IBA 01/2012 - 12/2007
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2016
3	AMP-Activated Protein KinasesIBA 01/2017 - 01/2008
3	Sirolimus (Rapamycin)FDA Link 03/2011 - 01/2008
2	nitazoxanide (NTZ)FDA Link 01/2022 - 01/2021
2	Transcription Factors (Transcription Factor)IBA 01/2020 - 12/2009
2	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2012 - 12/2007
2	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2012 - 12/2007
2	Phosphotransferases (Kinase)IBA 01/2012 - 12/2009
2	CollagenIBA 01/2012 - 12/2007
2	4- ((3- bromophenyl)amino)- 6,7- dimethoxyquinazolineIBA 05/2010 - 12/2009
2	Leucine (L-Leucine)FDA Link 12/2009 - 01/2008
2	Insulin (Novolin)FDA Link 12/2009 - 12/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2009 - 07/2006
2	Interleukin-6 (Interleukin 6)IBA 12/2009 - 01/2008
2	Antihypertensive Agents (Antihypertensives)IBA 11/2009 - 06/2008
2	Proteins (Proteins, Gene)FDA Link 01/2008 - 12/2007
2	salicylhydroxamic acid (SHAM)IBA 10/2006 - 04/2003
1	PlacebosIBA 10/2022
1	BCG Vaccine FDA Link 10/2022
1	VaccinesIBA 10/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2021
1	AntibodiesIBA 01/2021
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 10/2018
1	Immunologic Factors (Immunomodulators)IBA 10/2018
1	Monoclonal AntibodiesIBA 10/2018
1	LipopolysaccharidesIBA 01/2012
1	Peptides (Polypeptides)IBA 11/2011
1	Myosins (Myosin)IBA 11/2011
1	compound FP 1IBA 11/2011
1	NADPH Oxidases (NAD(P)H oxidase)IBA 08/2011
1	SodiumIBA 05/2011
1	Mitochondrial DNA (mtDNA)IBA 03/2011
1	Cyanides (Isocyanides)IBA 05/2010
1	anilinoquinazolineIBA 05/2010
1	Amino Acids FDA Link 12/2009
1	Atrial Natriuretic Factor (ANF)IBA 12/2009
1	Nonesterified Fatty Acids (NEFA)IBA 12/2009
1	Glucose (Dextrose)FDA LinkGeneric 12/2009
1	Pharmaceutical PreparationsIBA 12/2009
1	NF-kappa B (NF-kB)IBA 12/2009
1	Insulin Receptor Substrate ProteinsIBA 12/2009
1	C-Reactive ProteinIBA 11/2009
1	pyrimidineIBA 10/2008
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2008
1	Enalapril FDA LinkGeneric 10/2008
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2008
1	LeptinIBA 01/2008
1	AICA ribonucleotide (ZMP)IBA 01/2008
1	Antisense OligonucleotidesIBA 04/2007
1	Uncoupling Protein 2IBA 04/2007
1	Adenosine Triphosphate (ATP)IBA 04/2007
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 04/2007
1	CalciumIBA 10/2006
1	Adenosine (Adenocard)FDA LinkGeneric 07/2005
1	Phosphatidylinositols (Phosphatidylinositol)IBA 12/2003
1	Mitogen-Activated Protein KinasesIBA 12/2003

Therapy/Procedure

4	Therapeutics 01/2021 - 04/2007
3	High-Protein Diet 01/2017 - 01/2008
1	Immunotherapy 10/2018
1	Intraperitoneal Injections 01/2012